Mirkin’s research has been in the general area of vibrational spectroscopic studies of peptide and protein structure. Over the years, her research interests have included a variety of topics in experimental infrared and Raman spectroscopy; normal mode analysis; surface enhanced Raman spectroscopy; quantum chemical studies of structures, energies and force fields of macromolecules. Her recent work has concentrated in obtaining force fields by ab initio methods to be used in the development of spectroscopically reliable molecular mechanics energy functions for molecular dynamics of macromolecules.
She has served the American Physical Society as a member of the Executive Committee of the Forum on International Physics. She is currently serving in the Executive Committee of the Biophysics Research Division of the University of Michigan. She has also held leadership roles in the Association of Women in Science, the Council of the Michigan Chapter of Sigma Xi, the University of Michigan Hispanic Alumni Council, and the National Board of Directors of the University of Michigan Alumni Association. She is a member of Sigma Xi, the Society for Applied Spectroscopy, AAAS, the National Society of Hispanic Physicists, and the Society for the Advancement of Chicanos and Native Americans in Science.