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University of Toronto
Massively scaled-out microfluidic device for the in-flow formation and perfusion of a 3-D vascularized biomaterial. The device consists of up to ten stacked up silicon elastomer layers forming an array of approximately one hundred microchannels which serve to distribute the working fluids (aqueous alginate and calcium chloride) across the multilayered device. Formation of the biomaterial occurs under a polymerization process where alginate (grey) mixes through diffusion with calcium chloride (orange) at the device exit. The vascularized biomaterial produced can be subsequently perfused through the porous streams previously occupied by calcium chloride. Scale bar 2mm.
This work was funded by NSERC, OGS, Early Researcher Award.
Reporters can freely use this image. Credit: Lian Leng and Axel Guenther, University of Toronto.