Bacterial Microcolonies

;3 Lev Tsimring 2014
Tal Danino (MIT), Jeff Hasty (UCSD), Lev Tsimring (UCSD)

A periodic sequence of fluorescent flashes in a growing colony of bacteria E. coli containing synthetic gene circuits that generate periodic oscillations of gene expression.

UCSD researchers use biological "parts" to engineer small gene circuits within living cells that demonstrate complex dynamical behavior. In this work they employed quorum-sensing machinery to synchronize synthetic gene oscillators. This image shows one of a periodic sequence of fluorescent flashes in a growing colony of bacteria E.coli containing synthetic gene circuits that generate periodic oscillations of gene expression. Cells communicate and synchronize by producing and responding to signaling molecules AHL (Acyl Homoserine Lactone).

Related Abstract

Gray arrow  http://meeting.aps.org/Meeting/MAR14/Event/218104